Lysodren for Dogs

Lysodren is a drug that is used to treat the symptoms of Cushing's disease in dogs , a serious illness that is caused by tumors of the adrenal or pituitary glands. It is a form of mitotane, a drug that reduces the amount of hormones produced by the adrenal glands by destroying portions of them. Because the effects of Cushing's disease are a result of overproduction of these hormones, Lysodren can reestablish the hormonal balance of your dog and eliminate the symptoms. However, it can't really do anything to get rid of the tumors that cause Cushings.


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Also, some dogs do not respond to this drug. Your vet may want to try several other treatments for dogs with Cushing's disease, which include Anipryl, Lysodren, Nizoral, Eldepryl, and Ketoconazole.

Are there any side effects?

Yes - in fact, it has to be used very carefully and under close supervision because of the risks. There is a danger of overdosing the dog, which can result in the complete destruction of the adrenal glands. This leads to a condition called Addison's disease, which will need its own treatment, and if it is not noticed will kill the dog. In rare, very severe cases of Cushing's, some vets have recommended doing this on purpose. In essence, by killing off the entire adrenal gland you are trading Cushing's disease, a disease involving overproduction of hormones, for Addison's, a disease involving their underproduction.

Some dogs will experience other side effects using Lysodren. These include loss of appetite, vomiting, depression, and diarrhea. You should watch closely for these and any other side effects your vet warns you about.

Can it be given to cats?

It has been given to cats in some cases, sometimes with success. There is less experience in this area because cats do not get Cushing's disease nearly as often as dogs do. Vets thus do not have as much to go on and will often try the drugs that are better-tested in dogs.

Where can I buy Lysodren?

Lysodren 500 mg (per tablet)

Lysodren 500 mg (per tablet)

Lysodren (mitotane) is used in veterinary medicine to treat dogs with Cushing's disease. A prescription is required for this product. Click here for details

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